The Video Game Frog appears in the episode "What is Life?" It is an enemy in Battle Babe who fires magical missiles at Video Game Girl. The frog is surrounded by flies and could not be killed because of Ice King's lack of skills.
It is similar to Sleepy Sam, the frog boss of the game Guardians of Sunshine, except for a few key differences: Sleepy Sam eats the protagonist and has textured (edges and faces) graphics, whereas the video game frog shoots magic missiles and has wireframe (edge-only) graphics.