The lumps is a disease in the Land of Ooo. If someone is bitten by a Lumpy Space Person, they begin to turn lumpy until they are one of the Lumpy Space People. According to Lumpy Space Princess, the process follows "werewolf rules."
Symptoms of this change include the sporadic growth of uneven lumps all over the body and radical changes in opinion about anything from music to best friends. Once the lumpification is near complete, the infected individual starts floating like a Lumpy Space Person, and after the transformation is complete, the infected individual becomes full-on sassy.
Jake's transformation makes the process of attitude changing very obvious. In the final stages of lumpification, he tells Finn and Lumpy Space Princess he will never turn his back on Finn. He then completes the transformation and goes to Promcoming with Lumpy Space Princess saying all he needs to do is "turn my back on this guy."
The lumps must be cured by sunset or else the infected person will be lumpy forever. The disease can be cured by sitting on the lumps antidote, which is a small white sphere. While the antidote permanently cures a person infected with the lumps, a native Lumpy Space person turns smooth as long as they sit on it. In "Trouble in Lumpy Space," the antidote was owned by Lenny, Monty, and Glasses until they gave it to Finn. Finn soon cured himself and Jake, preventing them from becoming lumpy forever.
- This may be a reference to the Mumps disease or elephantiasis.
- In "Elements" it is revealed the lumps are the anti-element that undoes the magic of the four elementals (fire, ice, candy and slime) with Lumpy Space Princess being the incarnation of the lumpy anti-elemental. This is somewhat ironic because the lumps mirrors the effects of the elemental spell in which victims are physically transformed and take on the associated personality of the respective element even though it's said to be an anti-element.