Her first appearance was in "The Duke": after Princess Bubblegum is turned green and bald by a magic potion, Dr. Ice Cream attempts to treat her, by putting her in a medicinal milk suit. When Jake enters the room, she gives him an annoyed look when he laughs after seeing Princess Bubblegum. When the Princess becomes distraught about the whole situation, she tries to comfort her, saying that she will return to normal in five days. She also appeared as a train passenger in the episode "Mystery Train," in which she was one of the last candy people to be "murdered". She appeared in the episode "Mortal Recoil" where she attempted to revive Princess Bubblegum after a near-death experience. Her last appearance so far was in "No One Can Hear You", were she was one of the candy people in the crowd at the beginning of the episode.
Dr. Ice Cream looks like a regular soft-serve ice cream cone. Her "hair" is chocolate soft-serve ice cream and her body is a standard ice cream cone. She wears a white lab coat, and appears to have a small blue horse in her front pocket, which turns out to be a parasite that feeds off of smart brain waves, which appears in all of the doctors' pockets in Ooo, except for Doctor Donut, (who doesn't have pockets.)