Her first appearance was in "The Duke." After Princess Bubblegum is turned green and mostly hairless by a magic potion, Dr. Ice Cream attempts to treat her by putting her in a milk suit. When Jake enters the room and laughs at Princess Bubblegum, she gives him an annoyed look. When the Princess becomes distraught about the whole situation, Dr. Ice Cream tries to comfort her, saying that she will return to normal in five days.
She also appeared as a train passenger in the episode "Mystery Train," in which she was one of the last candy people to be "murdered."
She appeared in the episode "Mortal Recoil" where she attempted to revive Princess Bubblegum after a near-death experience.
Her last appearance so far was in "No One Can Hear You," where she was one of the candy people in the crowd at the beginning of the episode.
Dr. Ice Cream looks like a regular soft-serve ice cream cone. Her "hair" is chocolate soft-serve ice cream (and a little appears to be dripping) and her body is a standard ice cream cone, though the bottom is longer than usual. She wears a white lab coat, and appears to have a small blue horse in her front pocket, which is a parasite that feeds off smart brain waves.